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10.1038/nrm782 24 De BundelD.FafouriA.CsabaZ.LoyensE.LebonS.El GhouzziV.et al (2015)
Figure 13: Photograph of nurses administering insulin shock therapy in Lngbro Hospital, Stockholm, in 1930, credit: Wikipedia
Since evidencebased appropriate dosage for NAC in MS patients is scarce, the recommended dose was chosen based on the results of a previous study on patients with high oxidative stress conditions, which indicated that a higher dose than 1200 mg NAC per day might not be needed for GSH increments accompanied by gastrointestinal side effects
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